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Article

Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2015

Miyanaga Akihiko, Masuda Mari, Tsuta Koji, Kawasaki Kumiko, Nakamura Yuka, Sakuma Tomohiro, Asamura Hisao, Gemma Akihiko, Yamada Tesshi

Abstract excerpt

INTRODUCTION: Malignant mesothelioma (MM) is an aggressive neoplasm causatively associated with exposure to asbestos. MM is rarely responsive to conventional cytotoxic drugs, and the outcome remains dismal. It is, therefore, necessary to identify the signaling pathways that drive MM and to develo...

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Source

Identifiers

PMID: 25902174
DOI: 10.1097/JTO.0000000000000493

Genes

LATS1
LATS2
PSEN1
RASSF1
SAV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25902174-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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