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Article

Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma.

Cancer research - 15 Jan 2015

Guo Guangwu, Chmielecki Juliann, Goparaju Chandra, Heguy Adriana, Dolgalev Igor, Carbone Michele, Seepo Sara, Meyerson Matthew, Pass Harvey I

Abstract excerpt

Malignant pleural mesothelioma (MPM) is an aggressive neoplasm associated with asbestos exposure. Although previous studies based on candidate gene approaches have identified important common somatic mutations in MPM, these studies have focused on small sets of genes and have provided a limited view of the genetic alterations underlying this disease. Here, we performed whole-exome sequencing on DNA from 22 MPMs...

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Source

Identifiers

PMID: 25488749
DOI: 10.1158/0008-5472.CAN-14-1008

Genes

BAP1
CUL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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