Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations.

doi:10.1038/ng.3520

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Article

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations.

Nature genetics - 1 Apr 2016

Bueno Raphael, Stawiski Eric W, Goldstein Leonard D, Durinck Steffen, De Rienzo Assunta, Modrusan Zora, Gnad Florian, Nguyen Thong T, Jaiswal Bijay S, Chirieac Lucian R, Sciaranghella Daniele, Dao Nhien, Gustafson Corinne E, Munir Kiara J, Hackney Jason A, Chaudhuri Amitabha, Gupta Ravi, Guillory Joseph, Toy Karen, Ha Connie, Chen Ying-Jiun, Stinson Jeremy, Chaudhuri Subhra, Zhang Na, Wu Thomas D, Sugarbaker David J, de Sauvage Frederic J, Richards William G, Seshagiri Somasekar

Abstract excerpt

We analyzed transcriptomes (n = 211), whole exomes (n = 99) and targeted exomes (n = 103) from 216 malignant pleural mesothelioma (MPM) tumors. Using RNA-seq data, we identified four distinct molecular subtypes: sarcomatoid, epithelioid, biphasic-epithelioid (biphasic-E) and biphasic-sarcomatoid (biphasic-S). Through exome analysis, we found BAP1, NF2, TP53, SETD2, DDX3X, ULK2, RYR2, CFAP45, SETDB1 and DDX51 to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26928227
DOI: 10.1038/ng.3520

Genes

BAP1
SETD2
TRAF7
CFAP45
DDX51
RYR2
SETDB1
ULK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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