Article

A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer’s disease

2024-02-06

Abstract excerpt

<h4> Abstract </h4> While efforts to identify microglial subtypes have recently accelerated, the relation of transcriptomically defined states to function has been largely limited to in silico annotations. Here, we characterize a set of pharmacological compounds that have been proposed to polarize human microglia towards two distinct states – one enriched for AD and MS genes and another characterized by increas...

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Literature Corpus work: e7605b5c-197d-5f5d-926e-ee97de69457f
DOI: 10.1101/2024.02.06.579103

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