ELITE: E3 Ligase Inference for Tissue specific Elimination: A LLM Based E3 Ligase Prediction System for Precise Targeted Protein Degradation

Abstract excerpt

Targeted protein degradation (TPD) has transformed modern drug discovery by harnessing the ubiquitin–proteasome system to eliminate disease-driving proteins previously deemed undruggable. However, current approaches predominantly rely on a narrow set of ubiquitously expressed E3 ligases, such as Cereblon (CRBN) and Von Hippel–Lindau (VHL), which limits tissue specificity, increases systemic toxicity, and fosters r...

Topics

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• Binding Sites
• Deep Learning
• Mutation
• Protein Binding
• Protein Degradation and Inhibitors
• Repressor Proteins
• Substrate Specificity
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

fe398b3b-fa69-53a9-84e2-972d5a7fbc8a

DOI

10.1101/2025.11.05.686884