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Combinatorial mapping of E3 ubiquitin ligases to their target substrates

1 Feb 2025

Abstract excerpt

E3 ubiquitin ligases (E3s) confer specificity of protein degradation through ubiquitination of substrate proteins. Yet, the vast majority of the >600 human E3s have no known substrates. To identify proteolytic E3-substrate pairs at scale, we developed combinatorial mapping of E3 targets (COMET), a framework for testing the role of many E3s in degrading many candidate substrates within a single experiment. We...

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PMID: 39919746
DOI: 10.1016/j.molcel.2025.01.016

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