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Article

Mapping of Phenotype Specific Host-Microbiome Protein-Protein Interaction Networks in Colorectal Cancer Using Deep Learning.

International journal of molecular sciences - 9 May 2026

Kiouri Despoina P, Batsis Georgios C, Messaritakis Ippokratis, Souglakos John, Chasapis Christos T

Abstract excerpt

Colorectal cancer (CRC) pathogenesis is driven by complex protein-protein interactions (PPIs) between the host and the gut microbiome, yet these molecular dialogs remain largely unmapped. This study utilizes a Deep Learning framework, enhanced by protein structure embeddings, to predict approximately 8.9 billion interspecies PPIs from clinical metagenomic data. The model achieved high accuracy with an AUROC of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42196214
DOI: 10.3390/ijms27104232
PMCID: PMC13206771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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