Article

Hotspot propensity across mutational processes

2022-09-17

Abstract excerpt

The ability to study mutation rate variability at nucleotide resolution is impaired by the sparsity of observed mutational events across the genome. To circumvent this problem, here we investigated the propensity of 14 different mutational processes to form recurrently mutated sites across tumour samples (hotspots). We found that mutational signatures 1 (SBS1) and 17 (SBS17a and SBS17b) have the highest propensity...

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Literature Corpus work: e98dcf94-3be7-5862-a5f4-8f4b0d3262dc
DOI: 10.1101/2022.09.14.507952

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