Article

Comparing the predictors of mutability among healthy human tissues inferred from mutations in single cell genome data

2023-11-29

Abstract excerpt

Studying mutation in healthy somatic tissues is key for understanding the genesis of cancer and other genetic diseases. Mutation rate varies from site to site in the human genome by up to 100-fold and is influenced by numerous epigenetic and genetic factors including GC content, trinucleotide sequence context, and DNAse accessibility. These factors influence mutation at both local and regional scales and are often...

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Literature Corpus work: 7dadd56a-f0d2-5d46-95e4-17961575ebab
DOI: 10.1101/2023.11.28.569048

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