Determinants of mutation susceptibility along the genome are largely invariant across human tissues.

Abstract excerpt

BACKGROUND: The propensity for accumulating somatic mutations varies along the genome, which critically influences somatic mosaicism, tumor evolution and the potential role of somatic mutations in the context of age-associated diseases. Genomic factors contributing to the variability of mutation rates have been established, including, for example, distance from the replication origin, chromatin structure and...

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