Article

Passenger Hotspot Mutations in Cancer

2019-06-19

Abstract excerpt

Hotspots, or mutations that recur at the same genomic site across multiple tumors, have been conventionally interpreted as strong universal evidence of somatic positive selection, unequivocally pinpointing genes driving tumorigenesis. Here, we demonstrate that this convention is falsely premised on an inaccurate statistical model of background mutagenesis. Many hotspots are in fact passenger events, recurring at s...

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Literature Corpus work: 20f57cd0-5491-5e47-8e45-ccc06c4a5c45
DOI: 10.1101/675801

Open publication

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