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Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

24 Jan 2019

Abstract excerpt

Abstract Microglia, the resident immune cells of the brain, have important roles in brain health. However, little is known about the regulation and consequences of microglial activation in the aging human brain. Here we report that the proportion of morphologically activated microglia (PAM) in postmortem cortical tissue is strongly associated with β-amyloid, tau-related neuropathology, and the rate of cognitive...

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PMID: 30679421
DOI: 10.1038/s41467-018-08279-3

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