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Article

Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain.

Molecular neurodegeneration - 24 Jul 2018

Felsky Daniel, Patrick Ellis, Schneider Julie A, Mostafavi Sara, Gaiteri Chris, Patsopoulos Nikolaos, Bennett David A, De Jager Philip L

Abstract excerpt

BACKGROUND: The role of the innate immune system in Alzheimer's disease (AD) and neurodegenerative disease susceptibility has recently been highlighted in genetic studies. However, we do not know whether risk for inflammatory disease predisposes unaffected individuals to late-life cognitive deficits or AD-related neuropathology. We investigated whether genetic risk scores for seven immune diseases and central...

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Identifiers

PMID: 30041668
DOI: 10.1186/s13024-018-0272-6
PMCID: PMC6057096

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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