Article
Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3'UTR intron-containing NMD targets.
PLoS genetics - 1 Jun 2020
Gangras Pooja, Gallagher Thomas L, Parthun Michael A, Yi Zhongxia, Patton Robert D, Tietz Kiel T, Deans Natalie C, Bundschuh Ralf, Amacher Sharon L, Singh Guramrit
Abstract excerpt
Many post-transcriptional mechanisms operate via mRNA 3'UTRs to regulate protein expression, and such controls are crucial for development. We show that homozygous mutations in two zebrafish exon junction complex (EJC) core genes rbm8a and magoh leads to muscle disorganization, neural cell death, and motor neuron outgrowth defects, as well as dysregulation of mRNAs subjected to nonsense-mediated mRNA decay (NMD)...
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