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Article

Oncogenic Wnt/STOP signaling regulates ribosome biogenesis <i>in vivo</i>

2018-05-20

Abstract excerpt

Activating mutations in the Wnt pathway drive a variety of cancers, but the specific targets and pathways activated by Wnt ligands are not fully understood. To bridge this knowledge gap, we performed a comprehensive time-course analysis of Wnt-dependent signaling pathways in an orthotopic model of Wnt-addicted pancreatic cancer, using a PORCN inhibitor currently in clinical trials, and validated key results in add...

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Identifiers and source

Literature Corpus work
22ee0f2d-720d-5b41-90dc-1250ffa5b911
DOI
10.1101/326819
Open publication

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Oncogenic Wnt/STOP signaling regulates ribosome biogenesis <i>in vivo</i>DOI 10.1101/326819
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