Article

Stop codon-proximal 3′UTR introns in vertebrates can elicit EJC-dependent Nonsense-Mediated mRNA Decay

2019-06-21

Abstract excerpt

The Exon Junction Complex (EJC) regulates many steps in post-transcriptional gene expression and is essential for cellular function and organismal development; however, EJC-regulated genes and genetic pathways during development remain largely unknown. To study EJC function during zebrafish development, we first established that zebrafish EJCs mainly bind ∼24 nucleotides upstream of exon-exon junctions, and are al...

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Literature Corpus work: 0fdabb51-078f-5e05-aacf-393bb0c7f577
DOI: 10.1101/677666

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