Article

Developmentally regulated <i>tcf7l2</i> splice variants mediate transcriptional repressor functions during eye formation

2019-04-12

Abstract excerpt

Tcf7l2 mediates Wnt/β-Catenin signalling during development and is implicated in cancer and type-2 diabetes. The mechanisms by which Tcf7l2 and Wnt/β-Catenin signalling elicits such a diversity of biological outcomes are poorly understood. Here, we study alternatively spliced tcf7l2 in zebrafish and show that only splice variants that include exon 5 and an analogous human tcf7l2 variant can effectively provide c...

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Literature Corpus work: 2e9d604b-40a9-52fa-90e3-89dff16bbc78
DOI: 10.1101/607713

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