Article

Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape

2023-12-29

Abstract excerpt

<h4>Summary</h4> Despite exciting developments in cancer immunotherapy, its broad application is limited by the paucity of targetable antigens on the tumor cell surface. As an intrinsic cellular pathway, nonsense-mediated decay (NMD) conceals neoantigens through the destruction of the RNA products from genes harboring truncating mutations. We developed and conducted a high throughput screen, based on the ratiomet...

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Literature Corpus work: bc322e6a-80e5-5ffe-a5ff-7800fd79a058
DOI: 10.1101/2023.12.28.573594

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