Escape from nonsense mediated decay associates with anti-tumor immunogenicity

Abstract excerpt

Frameshift insertion/deletions (fs-indels) are an infrequent but potentially highly immunogenic mutation subtype. Although fs-indel transcripts are susceptible to degradation through the non-sense mediated decay (NMD) pathway, we hypothesise that some fs-indels escape degradation and lead to an increased abundance of tumor specific neoantigens, that are highly distinct from self. We analysed matched DNA and RNA se...

Topics

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• CAR-T cell therapy research
• Computer Simulation
• Frameshift Mutation
• Immunotherapy and Immune Responses
• Mutation, Missense
• Nonsense Mediated mRNA Decay
• Peptidase Inhibition and Analysis
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

06f9466b-5d87-5e76-9aa3-5264719e6403

DOI

10.1101/823716