Article

Disentangling Cell-Type-Specific Perturbation Responses Via Non-Negative Matrix Factorization of Bulk PFC Transcriptomes

2026-05-13

Abstract excerpt

Bulk transcriptomic profiling of the prefrontal cortex (PFC) provides a global snapshot of gene expression, but obscures cell-type-specific responses to genetic or environmental perturbations. Deconvolving these hidden signals remains a critical challenge, as cell-type heterogeneity can mask disease-relevant transcriptional changes. Here, we present an analytical framework based on non-negative matrix factorizatio...

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Literature Corpus work: e968b10f-5383-5b7b-8454-a41975252fbe
DOI: 10.14293/pr2199.003582.v1

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Disentangling Cell-Type-Specific Perturbation Responses Via Non-Negative Matrix Factorization of Bulk PFC TranscriptomesDOI 10.14293/pr2199.003582.v1Read

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