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Bacterial Protein Secretion Is Required for Priming of CD8+T Cells Specific for theMycobacterium tuberculosisAntigen CFP10

1 Jul 2008

Abstract excerpt

Mycobacterium tuberculosis infection elicits antigen-specific CD8(+) T cells that are required to control disease. It is unknown how the major histocompatibility complex class I (MHC-I) pathway samples mycobacterial antigens. CFP10 and ESAT6 are important virulence factors secreted by M. tuberculosis, and they are immunodominant targets of the human and murine T-cell response. Here, we test the hypothesis that...

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PMID: 18591224
DOI: 10.1128/iai.00307-08

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