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Article

ESX-1 dependent impairment of autophagic flux by<i><i>Mycobacterium tuberculosis</i></i>in human dendritic cells

10 Aug 2012

Abstract excerpt

Emerging evidence points to an important role of autophagy in the immune response mediated by dendritic cells (DC) against Mycobacterium tuberculosis (Mtb). Since current vaccination based on Bacillus Calmette-Guerin (BCG) is unable to stop the tuberculosis epidemic, a deeper comprehension of the alterations induced by Mtb in DC is essential for setting new vaccine strategies. Here, we compared the capacity of...

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PMID: 22885411
DOI: 10.4161/auto.20881

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