Article
iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.
Molecular and cellular neurosciences - 1 Sept 2024
Theofilas Panos, Wang Chao, Butler David, Morales Dulce O, Petersen Cathrine, Ambrose Andrew, Chin Brian, Yang Teddy, Khan Shireen, Ng Raymond, Kayed Rakez, Karch Celeste M, Miller Bruce L, Gestwicki Jason E, Gan Li, Temple Sally, Arkin Michelle R, Grinberg Lea T
Abstract excerpt
BACKGROUND: Tau post-translational modifications (PTMs) result in the gradual build-up of abnormal tau and neuronal degeneration in tauopathies, encompassing variants of frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD). Tau proteolytically cleaved by active caspases, including caspase-6, may be neurotoxic and prone to self-aggregation. Also, our recent findings show that caspase-6 truncated...
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