Article

Caspase-6-cleaved tau is relevant in Alzheimer’s disease but not in other tauopathies: diagnostic and therapeutic implications

2021-02-01

Abstract excerpt

<h4>Aim</h4> Tau truncation (tr-tau) by active caspase-6 (aCasp-6) generates toxic tau fragments prone to self-aggregation. Yet, the relationship between aCasp-6, different forms of tr-tau, and hyperphosphorylated tau (p-tau) accumulation in human brains with Alzheimer’s disease (AD) and other tauopathies remains unclear. <h4>Methods</h4> We generated two neoepitope monoclonal antibodies against tr-tau sites (D4...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3438bdd3-7eb9-5c33-8889-1473998c5c69
DOI: 10.1101/2021.01.28.21250322

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Caspase-6-cleaved tau is relevant in Alzheimer’s disease but not in other tauopathies: diagnostic and therapeutic implicationsDOI 10.1101/2021.01.28.21250322Read

Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's DiseaseSemantic proximity Read

iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell deathSemantic proximity Read

Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M <i>MAPT</i> mutationSemantic proximity Read

Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease modelsSemantic proximity Read

Progress regarding the context-of-use of tau as biomarker of Alzheimer’s disease and other neurodegenerative diseasesSemantic proximity Read

Necroptosis and Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic OpportunitiesSemantic proximity Read

Invited review: Neuropathology of tauopathies: principles and practice.Semantic proximity Read

Molecular Pathogenesis of the TauopathiesSemantic proximity Read

iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.Semantic proximity Read

Tauopathies: new perspectives and challengesSemantic proximity Read

N-terminal tau truncation in the pathogenesis of Alzheimer's disease (AD): Developing a novel diagnostic and therapeutic approachSemantic proximity Read

Tau; One Protein, So Many DiseasesSemantic proximity Read