Article

Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M <i>MAPT</i> mutation

2021-01-09

Abstract excerpt

Tau post-translational modifications (PTMs) are associated with progressive tau accumulation and neuronal loss in tauopathies, including forms of frontotemporal lobar degeneration (FTLD) and Alzheimer’s disease (AD). Proteolytic cleavage of tau by active caspases, including caspase-6, represents an underexplored tau PTM implicated in tau pathology. Caspase-cleaved tau is toxic and prone to self-aggregation in expe...

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Literature Corpus work: a6f5ec32-e4f2-5477-b0ad-bac76625f17c
DOI: 10.1101/2021.01.08.425912

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