Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations.

Stem cell reports - 13 Sept 2016

Biswas Md Helal U, Almeida Sandra, Lopez-Gonzalez Rodrigo, Mao Wenjie, Zhang Zhijun, Karydas Anna, Geschwind Michael D, Biernat Jacek, Mandelkow Eva-Maria, Futai Kensuke, Miller Bruce L, Gao Fen-Biao

Abstract excerpt

How mutations in the microtubule-associated protein tau (MAPT) gene cause frontotemporal dementia (FTD) remains poorly understood. We generated and characterized multiple induced pluripotent stem cell (iPSC) lines from patients with MAPT IVS10+16 and tau-A152T mutations and a control subject. In cortical neurons differentiated from these and other published iPSC lines, we found that MAPT mutations do not affect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Cellular Reprogramming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Frontotemporal Dementia

Share to Induced Pluripotent Stem Cells

Share to Matrix Metalloproteinase 2

Share to Matrix Metalloproteinase 9

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27594586
DOI: 10.1016/j.stemcr.2016.08.006
PMCID: PMC5032669

Genes

MAPT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations.PMID 27594586Read ↗

Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein.Semantic proximity Read ↗

Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCsSemantic proximity Read ↗

Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cellsSemantic proximity Read ↗

iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell deathSemantic proximity Read ↗

The TAU isoform 1N4R restores vulnerability of MAPT knockout human iPSC-derived neurons to Amyloid beta-induced neuronal dysfunctionSemantic proximity Read ↗

iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.Semantic proximity Read ↗

Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.Semantic proximity Read ↗

Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with<i>MAPT</i>mutationsSemantic proximity Read ↗

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.Semantic proximity Read ↗

Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.Semantic proximity Read ↗

Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M <i>MAPT</i> mutationSemantic proximity Read ↗

Human Induced Pluripotent Stem Cell Models of Frontotemporal Dementia With Tau PathologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.