Correspondence of fentanyl brain pharmacokinetics and behavior measured via engineering opioids biosensors and computational ethology

Abstract excerpt

Despite the ongoing epidemic of opioid use disorder and death by fentanyl overdose, opioids remain the gold standard for analgesics. Pharmacokinetics (PK) dictates the individual’s experience and utility of drugs; however, PK and behavioral outcomes have been conventionally studied in separate groups, even in preclinical models. To bridge this gap, we developed the first class of sensitive, selective, and genetica...

Topics

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• Behavior
• Disease Progression
• Drug Evaluation, Preclinical
• High-Throughput Screening Assays
• Mice
• Mice, Inbred C57BL
• Mice, Inbred DBA
• Phenotype

Identifiers and source

Literature Corpus work

e9361ce0-957c-50d3-855e-19906b1a76e2

DOI

10.1101/2024.03.15.584894