Article

A genetically encoded biosensor reveals location bias of opioid drug action

2018-01-26

Abstract excerpt

<h4>Summary</h4> Opioid receptors (ORs) precisely modulate behavior when activated by native peptide ligands but distort behaviors to produce pathology when activated by non-peptide drugs. A fundamental question is how drugs differ from peptides in their actions on target neurons. One way that drugs can differ is by imposing selective effects on the conformational equilibrium of individual ORs. We wondered if dru...

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Identifiers and source

Literature Corpus work: f21faf83-796f-5314-92b8-0cbe5bdc1622
DOI: 10.1101/254490

Open publication

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