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A hidden protamine PTM code in sperm generates heterogeneous chromatin states and finetunes reproductive fitness

2025-11-18

Abstract excerpt

Traditionally, the sperm genome is thought to be packaged by protamines into a uniformly compact and inert chromatin structure. Here, we challenge this long-standing view by demonstrating that protamine post-translational modifications (PTMs) present on distinct protamine molecules create discrete protamine-DNA chromatin states, ranging from weak to tightly associated chromatin configurations. Loss of these modifi...

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Identifiers and source

Literature Corpus work
e92e841c-eb66-5054-8497-06b8a2fd703a
DOI
10.1101/2025.11.18.688960
Open publication

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A hidden protamine PTM code in sperm generates heterogeneous chromatin states and finetunes reproductive fitnessDOI 10.1101/2025.11.18.688960
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