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Article

Essential Role of Histone Replacement and Modifications in Male Fertility

8 Oct 2019

Abstract excerpt

Spermiogenesis is a complex cellular differentiation process that the germ cells undergo a distinct morphological change, and the protamines replace the core histones to facilitate chromatin compaction in the sperm head. Recent studies show the essential roles of epigenetic events during the histone-to-protamine transition. Defects in either the replacement or the modification of histones might cause male...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Identifiers

PMID: 31649732
DOI: 10.3389/fgene.2019.00962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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