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Protamine expression in somatic cells condenses chromatin and disrupts transcription without altering DNA methylation

2025-06-03

Abstract excerpt

Protamines play a crucial role in nuclear condensation during spermiogenesis, a process that involves significant chromatin remodeling and the replacement of histones. While much research has focused on the function of protamines in sperm development and fertility, their effects in non-sperm cells remain largely unexplored. In this study, we investigated the impact of overexpressing murine and human protamine 1 an...

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Literature Corpus work
0213ba07-9bb5-57b1-ab10-c8ca4d6d127f
DOI
10.1101/2025.06.02.657337
Open publication

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Protamine expression in somatic cells condenses chromatin and disrupts transcription without altering DNA methylationDOI 10.1101/2025.06.02.657337
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