Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells.

doi:10.1016/j.molcel.2017.02.025

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Article

Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells.

Molecular cell - 6 Apr 2017

Barral Sophie, Morozumi Yuichi, Tanaka Hiroki, Montellier Emilie, Govin Jérôme, de Dieuleveult Maud, Charbonnier Guillaume, Couté Yohann, Puthier Denis, Buchou Thierry, Boussouar Fayçal, Urahama Takashi, Fenaille François, Curtet Sandrine, Héry Patrick, Fernandez-Nunez Nicolas, Shiota Hitoshi, Gérard Matthieu, Rousseaux Sophie, Kurumizaka Hitoshi, Khochbin Saadi

Abstract excerpt

Histone replacement by transition proteins (TPs) and protamines (Prms) constitutes an essential step for the successful production of functional male gametes, yet nothing is known on the underlying functional interplay between histones, TPs, and Prms. Here, by studying spermatogenesis in the absence of a spermatid-specific histone variant, H2A.L.2, we discover a fundamental mechanism involved in the...

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Identifiers

PMID: 28366643
DOI: 10.1016/j.molcel.2017.02.025

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