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Article

Histone variants: essential actors in male genome programming.

Journal of biochemistry - 1 Feb 2018

Hoghoughi Naghmeh, Barral Sophie, Vargas Alexandra, Rousseaux Sophie, Khochbin Saadi

Abstract excerpt

Prior to its transmission to the offspring, the male genome has to be tightly compacted. A genome-scale histone eviction and the subsequent repackaging of DNA by protamines (Prms) direct this essential genome condensation step. The requirement for male germ cells to undergo such a dramatic and unique genome reorganization explains why these cells express the largest number of histone variants, including many...

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PMID: 29165574
DOI: 10.1093/jb/mvx079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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