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Sperm chromatin structure: Insights from in vitro to in situ experiments

25 Mar 2022

Abstract excerpt

The sperm genome is tightly packed into a minimal volume of sperm nuclei. Sperm chromatin is highly condensed by protamines (PRMs) after histone-protamine replacement, and the majority of the sperm genome forms a nucleo-protamine structure, namely, the PRM-DNA complex. The outline of sperm chromatin structure was proposed 30 years ago, and the details have been explored by approaches from several independent...

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PMID: 35344802
DOI: 10.1016/j.ceb.2022.102075

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