Article

p16 <sup>INK4A</sup> expression induces paracrine senescence via small extracellular vesicles

2025-12-11

Abstract excerpt

<h4>ABSTRACT</h4> Senescent cells are characterized by the expression of the cell cycle inhibitor and biomarker of aging, p16 INK4A , and the capacity to modify the microenvironment through the senescence-associated secretory phenotype (SASP). Senescent cells accumulate in physiological and pathological conditions, including aging. In spite of this, fibroblasts ectopically expressing p16 INK4A do not release a...

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Literature Corpus work: e92ab769-3a50-5c98-8bf9-ff57489cb4b2
DOI: 10.64898/2025.12.09.689258

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