Cells exhibiting strong p16 INK4a promoter activation in vivo display features of senescence

Abstract excerpt

Significance The accumulation of senescent cells over a lifetime causes age-related pathologies; however, the inability to reliably identify senescent cells in vivo has hindered clinical efforts to employ this knowledge as a means to ameliorate or reverse aging. Here, we describe a reporter allele, p16 tdTom , enabling the in vivo identification and isolation of cells featuring high-level activation of the p16...

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• Share to Advanced biosensing and bioanalysis techniques
• Share to Single-cell and spatial transcriptomics
• Share to Telomeres, Telomerase, and Senescence