Article

Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesicles

2020-03-23

Abstract excerpt

<h4>ABSTRACT</h4> Cellular senescence is a potent tumor-suppressive program that prevents neoplastic events. Paradoxically, senescent cells develop an inflammatory secretome, termed the senescence-associated secretory phenotype (SASP) and implicated in age-related pathologies including cancer. Here we report that senescent cells actively synthesize and release small extracellular vesicles (sEVs) with a distinctiv...

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Literature Corpus work: 150e8d1e-5f09-5d8a-b41e-6348065acc3c
DOI: 10.1101/2020.03.22.002667

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