Article

Distinct secretomes in p16- and p21- positive senescent cells across tissues

2023-12-05

Abstract excerpt

<h4>SUMMARY</h4> Senescent cells drive age-related tissue dysfunction via the induction of a chronic senescence-associated secretory phenotype (SASP). The cyclin-dependent kinase inhibitors p21 Cip1 and p16 Ink4a have long served as markers of cellular senescence. However, their individual roles remain incompletely elucidated. Thus, we conducted a comprehensive examination of multiple single-cell RNA sequencing...

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Literature Corpus work: 24a0a16a-6c1b-5e17-9ced-84d9f2dd2237
DOI: 10.1101/2023.12.05.569858

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