Article

Early growth response 2 (EGR2) is a novel regulator of the senescence program

2020-10-01

Abstract excerpt

<h4>Summary</h4> Senescence, a state of stable growth arrest, plays an important role in ageing and age-related diseases in vivo . Although the INK4/ARF locus is known to be essential for senescence programs, the key regulators driving p16 and ARF transcription remain largely underexplored. Using siRNA screening for modulators of the p16/pRB and ARF/p53/p21 pathways in deeply senescent human mammary epithelial...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 64f9a9cd-01d1-53c5-8ac1-e3d4009eb566
DOI: 10.1101/2020.09.30.321190

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early growth response 2 (EGR2) is a novel regulator of the senescence programDOI 10.1101/2020.09.30.321190Read

Early growth response 2 (EGR2) is a novel regulator of the senescence programmeSemantic proximity Read

Modulation of the expression of p16<sup>INK4a</sup>and p14<sup>ARF</sup>by hnRNP A1 and A2 RNA binding proteins: Implications for cellular senescenceSemantic proximity Read

Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14 <sup>ARF</sup> Tumor SuppressorSemantic proximity Read

CREG1 enhances p16 INK4a -induced cellular senescenceSemantic proximity Read

Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescenceSemantic proximity Read

The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and HomeostasisSemantic proximity Read

miR-96-5p expression is sufficient to induce and maintain the senescent cell fate in the absence of stressSemantic proximity Read

p16 <sup>INK4A</sup> expression induces paracrine senescence via small extracellular vesiclesSemantic proximity Read

Involvement of the INK4a/Arf gene locus in senescence.Semantic proximity Read

Cellular senescence mediated by p16INK4A-coupled miRNA pathwaysSemantic proximity Read

Ink4a/Arf expression is a biomarker of agingSemantic proximity Read

Sentinel <i>p16</i> <sup> <i>INK4a</i> </sup> + cells in the basement membrane form a reparative niche in the lungSemantic proximity Read