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Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases

5 Dec 2012

Abstract excerpt

Aging is the main risk factor for most chronic diseases, disabilities, and declining health. It has been proposed that senescent cells--damaged cells that have lost the ability to divide--drive the deterioration that underlies aging and age-related diseases. However, definitive evidence for this relationship has been lacking. The use of a progeroid mouse model (which expresses low amounts of the mitotic...

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PMID: 23212104
DOI: 10.1038/clpt.2012.193

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