Article
Pervasive sharing of genetic effects in autoimmune disease.
PLoS genetics - 1 Aug 2011
Cotsapas Chris, Voight Benjamin F, Rossin Elizabeth, Lage Kasper, Neale Benjamin M, Wallace Chris, Abecasis Gonçalo R, Barrett Jeffrey C, Behrens Timothy, Cho Judy, De Jager Philip L, Elder James T, Graham Robert R, Gregersen Peter, Klareskog Lars, Siminovitch Katherine A, van Heel David A, Wijmenga Cisca, Worthington Jane, Todd John A, Hafler David A, Rich Stephen S, Daly Mark J
Abstract excerpt
Genome-wide association (GWA) studies have identified numerous, replicable, genetic associations between common single nucleotide polymorphisms (SNPs) and risk of common autoimmune and inflammatory (immune-mediated) diseases, some of which are shared between two diseases. Along with epidemiological and clinical evidence, this suggests that some genetic risk factors may be shared across diseases-as is the case...
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