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Genomic structural equation modeling elucidates the shared genetic architecture of allergic disorders

15 Apr 2025

Abstract excerpt

BACKGROUND: The intricate shared genetic architecture underlying allergic disorders-including allergic asthma, atopic dermatitis, contact dermatitis, allergic rhinitis, allergic conjunctivitis, allergic urticaria, anaphylaxis, and eosinophilic esophagitis-remains incompletely characterized. METHODS: Our study employed genomic structural equation modeling (Genomic SEM) to define the common factor representing the...

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PMID: 40234965
DOI: 10.1186/s12967-025-06465-8

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