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Article

Genomic structural equation modeling elucidates the shared genetic architecture of allergic disorders.

Journal of translational medicine - 15 Apr 2025

Ruan Jingsheng, Yi Xinglin

Abstract excerpt

BACKGROUND: The intricate shared genetic architecture underlying allergic disorders-including allergic asthma, atopic dermatitis, contact dermatitis, allergic rhinitis, allergic conjunctivitis, allergic urticaria, anaphylaxis, and eosinophilic esophagitis-remains incompletely characterized. METHODS: Our study employed genomic structural equation modeling (Genomic SEM) to define the common factor representing the...

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Identifiers

PMID: 40234965
DOI: 10.1186/s12967-025-06465-8
PMCID: PMC12001568

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