Article
Shared genetic variants suggest common pathways in allergy and autoimmune diseases.
The Journal of allergy and clinical immunology - 1 Sept 2017
Kreiner Eskil, Waage Johannes, Standl Marie, Brix Susanne, Pers Tune H, Couto Alves Alexessander, Warrington Nicole M, Tiesler Carla M T, Fuertes Elaine, Franke Lude, Hirschhorn Joel N, James Alan, Simpson Angela, Tung Joyce Y, Koppelman Gerard H, Postma Dirkje S, Pennell Craig E, Jarvelin Marjo-Riitta, Custovic Adnan, Timpson Nicholas, Ferreira Manuel A, Strachan David P, Henderson John, Hinds David, Bisgaard Hans, Bønnelykke Klaus
Abstract excerpt
BACKGROUND: The relationship between allergy and autoimmune disorders is complex and poorly understood. OBJECTIVE: We sought to investigate commonalities in genetic loci and pathways between allergy and autoimmune diseases to elucidate shared disease mechanisms. METHODS: We meta-analyzed 2 genome-wide association studies on self-reported allergy and sensitization comprising a total of 62,330 subjects. These...
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