Article

Phenotypes and Cellular Mechanics of Primary Human Aorta- and Pluripotent Stem Cell-derived Vascular Smooth Muscle Cells

2025-12-22

Abstract excerpt

<h4>Aims</h4> Mature, contractile vascular smooth muscle cells (vSMC) in the medial layer of muscular blood vessels can de-differentiate into synthetic vSMC, while human pluripotent stem cells (hPSC) differentiate into proliferating, fetal-like vSMC that can be induced to form contractile vSMC. Our aim was to define the mechanical properties of well-characterized in vitro-differentiated vSMC compared to vSMC deri...

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Literature Corpus work: e8dcf0fe-8abd-5983-92e6-51ad04e73569
DOI: 10.64898/2025.12.18.694995

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