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Article

Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates.

Cardiovascular research - 1 Dec 2012

Bajpai Vivek K, Mistriotis Panagiotis, Loh Yuin-Han, Daley George Q, Andreadis Stelios T

Abstract excerpt

AIMS: Smooth muscle cells (SMC) play an important role in vascular homeostasis and disease. Although adult mesenchymal stem cells (MSC) have been used as a source of contractile SMC, they suffer from limited proliferation potential and culture senescence, particularly when originating from older donors. By comparison, human induced pluripotent stem cells (hiPSC) can provide an unlimited source of functional SMC...

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Identifiers

PMID: 22941255
DOI: 10.1093/cvr/cvs253
PMCID: PMC3584971

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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