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Article

Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells

11 Oct 2012

Abstract excerpt

AIMS: Embryonic vascular smooth muscle cells (vSMCs) have a synthetic phenotype; in adults, they commit to the mature contractile phenotype. Research shows that human pluripotent stem cells (hPSCs) differentiate into vSMCs, but nobody has yet documented their maturation into the synthetic or contractile phenotypes. This study sought to control the fate decisions of hPSC derivatives to guide their maturation...

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PMID: 23060134
DOI: 10.1093/cvr/cvs315

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