Article
Embryonic domains of the aorta derived from diverse origins exhibit distinct properties that converge into a common phenotype in the adult.
Journal of molecular and cellular cardiology - 1 Apr 2014
Pfaltzgraff Elise R, Shelton Elaine L, Galindo Cristi L, Nelms Brian L, Hooper Christopher W, Poole Stanley D, Labosky Patricia A, Bader David M, Reese Jeff
Abstract excerpt
Vascular smooth muscle cells (VSMCs) are derived from distinct embryonic origins. Vessels originating from differing smooth muscle cell populations have distinct vascular and pathological properties involving calcification, atherosclerosis, and structural defects such as aneurysm and coarctation. We hypothesized that domains within a single vessel, such as the aorta, vary in phenotype based on embryonic origin....
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