Article

Ubiquitination of Smad2 by Smurf1 inhibits endothelial-to-mesenchymal transition in human coronary artery endothelial cells

2025-07-16

Abstract excerpt

<title>Abstract</title> <p>Smad2 is a well-established regulator involved in tissue development and in the pathogenesis of endothelial-to-mesenchymal transition (EndMT) mediated by TGF-β signaling. However, the mechanism underlying the regulation of Smad2 in human coronary artery endothelial cells (HCAECs), particularly the identity of the responsible E3 ubiquitin ligase and its role during EndMT remain unclear....

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Literature Corpus work: e8cd49db-27f3-57e9-a7fc-b7b11236910f
DOI: 10.21203/rs.3.rs-6878518/v1

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