FOXO1 unlocks SMAD function to drive mechano-induced endothelial-to-mesenchymal transition

Abstract excerpt

<title>Abstract</title> <p>Endothelial-to-mesenchymal transition (EndMT) contributes to vascular remodeling and endothelial dysfunction in diseases such as atherosclerosis and pulmonary arterial hypertension. This process describes a gradual shift in which endothelial cells (ECs) lose expression of classical EC markers and acquire mesenchymal-like gene expression patterns and phenotypic traits. Although SMAD tran...

Topics

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• Cells, Cultured
• DNA Primers
• Endothelium, Vascular
• Flow Cytometry
• Kruppel-Like Transcription Factors
• Reverse Transcriptase Polymerase Chain Reaction
• RNA, Small Interfering
• Umbilical Veins

Identifiers and source

Literature Corpus work

3cfc5b77-04c7-520c-8945-2dde82d38e17

DOI

10.21203/rs.3.rs-8347032/v1