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Article

FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2022

Zhu Xiaolong, Qiu Cong, Wang Yiran, Jiang Yuanqing, Chen Yefeng, Fan Linge, Ren Ruizhe, Wang Yunyun, Chen Yu, Feng Yanzhi, Zhou Xiaofei, Zhu Yunhui, Ge Zhen, Lai Dongwu, Qin Lingfeng, Simons Michael, Yu Luyang

Abstract excerpt

Angiogenesis contributes fundamentally to embryonic development, tissue homeostasis, and wound healing. Basic fibroblast growth factor (FGF2) is recognized as the first proangiogenic molecule discovered, and it facilitates angiogenesis by activating FGF receptor 1 (FGFR1) signaling in endothelial cells. However, the precise roles of FGFR and the FGF/FGFR signaling axis in angiogenesis remain unclear, especially...

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Share to Endothelial Cells
Share to Fibroblast Growth Factor 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia

Share to Membrane Proteins

Share to Neovascularization, Physiologic

Share to Receptor, Fibroblast Growth Factor, Type 1

Share to Sumoylation

Share to Vascular Endothelial Growth Factor Receptor-2

Source

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Identifiers

PMID: 35733256
DOI: 10.1073/pnas.2202631119
PMCID: PMC9245619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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